The role Time in range depending on the method of assessing glycemic control in diabetes: A review

Abstract

Despite modern advances in diabetology, diabetes is a progressive non-communicable disease with the possible development of vascular complications, which is a global health problem. Therefore, maintaining optimal glycemic control is important for managing diabetes and preventing the development of acute and chronic complications of the disease. One of the parameters for assessing glycemic control is the indicator of time in the target range (Time in range TIR), calculated on the basis of data from continuous glucose monitoring (CGM), which is quite simple and convenient to calculate and use, and also has a proven connection with the development of micro- and macrovascular complications of diabetes. However, the main obstacle to the widespread use of TIR is the limited use of CGM systems. Therefore, of particular interest is the study of the derived indicator of the time in range of glycemia (derived TIR dTIR), obtained on the basis of self-monitoring of blood glucose. In this review, the issues of the relationship of TIR, dTIR with HbA1c levels, the development of micro- and macrovascular complications of diabetes type 1 and 2 are discussed, and the comparability of TIR and dTIR is analyzed.