The Role of Zinc in Cancer Patients Suffering From Diabetic Disease or Hyperglycaemia and the Impacts in the New Immunotherapy Protocols

Abstract

Diabetes is a harmful metabolic disease (fasting hyperglycemia, intense thirst, mainly nocturnal diuresis, etc.) which afflicts millions of people worldwide and is correlated with environmental pollution and poor diet. The hyperglycemia of diabetic disease, supported by insulin resistance and hyperinsulinemia, is closely related to an increase in oncological, cardiovascular and chronic-degenerative diseases and to a worsening of any responses to therapeutic protocols. Our work proposes an insight into the lack of therapeutic response to immunotherapy and/or chemotherapy protocols in diabetic or hyperglycemic cancer patients. Lack of therapeutic response, in fact, occurs when a patient does not respond to a certain pathology because the body is unable to produce or activate specific lymphocytes and antibodies towards that disease. We argue that the lack of therapeutic response can be caused by deficiencies of trace elements such as Zinc, Copper, Manganese and Cobalt etc. Which help our body to improve its health condition and aggravated by toxic substances such as heavy metals, PCBs and other environmental pollutants. It therefore becomes essential to dose these substances in the various biological matrices (blood, hair, urine, modified tissues, etc.) and in the tumor to adequately deal with the neoplastic disease and reduce the possibility of a lack of therapeutic response.