The role of WDR76 protein in human diseases.

Jie Yang,Fei Wang,Baoan Chen

doi:10.17305/bjbms.2020.5506

Jie Yang, Fei Wang + Show 1 more

Open Access

https://doi.org/10.17305/bjbms.2020.5506

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Abstract

The WD40 repeat (WDR) domain is one of the most abundant protein interaction domains in the human proteome. More than 360 protein interaction domains have been annotated thus far. The WDR domains mediate interactions with peptide regions of important interaction partners in a variety of biological processes. Proteins with the WDR domain which typically contains a seven-bladed β propeller, are continuously being discovered. They represent a large class of proteins that are likely to play important roles. WD40 repeat domain-containing protein 76 (WDR76) is a member of WDR domain-containing proteins. Although it remains poorly understood, it is potentially involved in DNA damage repair, apoptosis, cell cycle progression, and gene expression regulation. Ongoing research on WDR76 is increasing the knowledge regarding its basic functions and role in different pathophysiological. The study of WDR76 is challenging due to the complexity of its interactions with its partners. In the present review, we summarized the current knowledge regarding WDR76, its physiological functions, the close relationship with human diseases, and potential opportunities for target therapy.

Highlights

With the research development with WD40 repeat (WDR) domain-containing proteins, play vital roles in diverse biological processes
The results showed that WD40 repeat domain-containing protein 76 (WDR76) was associated with DNA damage response proteins, such as poly(ADP-ribose) polymerase 1 (PARP1), poly(ADP-ribose) polymerase 1 (RPA1), replication protein A2 (RPA2), DNA-damage-binding protein 1 (DDB1), and poly(ADP-ribose) polymerase 1 (XRCC5), as well as heterochromatin related proteins, such as chromobox 1 (CBX1), chromobox 3 (CBX3), and chromobox 5 (CBX5)
As hepatic steatosis is one of the factors that can progress to hepatocellular carcinomas (HCC); this study provided new insights into the potential targeted treatment of hepatic steatosis through regulation of WDR76 expression to prevent the transformation of liver cells into cancer cells

Summary

Introduction

With the research development with WD40 repeat (WDR) domain-containing proteins, play vital roles in diverse biological processes. Owing to the complex structure of WDR domains, they often act as essential subunits of multiprotein complexes involved in a variety of cellular processes, including signaling transduction, DNA damage sensing and repair, the ubiquitin–proteasome system, cell growth and division, epigenetic regulation of gene expression and chromatin organization [3,4,5,6]. Further research studies on the function of WDR76, have demonstrated that it is involved in multiple distinct pathophysiological processes, in different diseases including tumorigenesis [14, 15].

Results

Conclusion