Abstract
The aim of the present study was to evaluate functional recovery in injured rabbit sciatic nerve using vitamin k and spinach. A total of 4 matured rabbits were used for the study. The rabbits were first trained to walk in the walking tract apparatus after which the normal Sciatic Function Index was obtained and calculated. A Cut‐induced peripheral nerve injury was performed on the sciatic nerves of rabbits in the four study groups after which the Sciatic Function Index of the rabbits were obtained using a walking tract apparatus a day after injury and subsequently one to three weeks after treatment with vitamin k and spinach. Rabbit 1 was not injured and was not treated, rabbit 2 was injured without treatment, rabbit 3 was injured and treated with 3ml/kg of spinach juice and rabbit 4 was injured and treated with 2g/kg vitamin k supplement. The Sciatic Function Index results show a percentage recovery in rabbit 3 an 4 after injury and treatment with vitamin k and spinach, while they were no significant change in the percentage recovery of the rabbit 2 (injured without treatment). The results obtained from rabbit 2 (injured without treatment) show recovery index of 0.18 and this was used to calculate the percentage recovery obtained to be 0.3%. The rabbit 3 (injured and treated with spinach) showed recovery index of 15.05 and this was used to calculate the percentage recovery obtained to be 21%, the result however justify some conclusion that spinach has functional recovery on injured sciatic nerve. The rabbit 4 (injured and treated with vitamin k) showed recovery index of 31.11 and this was used to calculate the percentage recovery obtained to be 39%, the result however support the role of vitamin K in sphingolipid metabolism and its modulation status and also the activation of vitamin k dependent proteins. The percentage recovery continued to increase in the injured rabbit treated with vitamin k and spinach and these results suggest and support the use of vitamin k for acceleration of peripheral nerve regeneration.Support or Funding InformationNilThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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