Year-end Sale % OFF 
Abstract
In the last decade, vitamin D was in the spotlight in many fields of research. Despite numerous publications, its influence on reproductive health remains ambiguous. This paper presents an up-to-date review of current knowledge concerning the role of cholecalciferol in human reproduction. It covers various infertility issues, such as polycystic ovary syndrome, endometriosis, myoma-induced infertility, male infertility, premature ovary failure and in vitro fertilization techniques. Vitamin D deficiency, defined as serum concentration of 25-hydroxycalciferol of less than 50 nmol/L, is commonly noted more frequently than only in fertility clinic patients. It is a global trend that is observed in all age groups. The results of original publications dated up to 2015 have been summarized and discussed in a critical manner. Most experts agree that vitamin D supplementation is a necessity, particularly in women suffering from obesity, insulin resistance or small ovarian reserve, as well as in men with oligo- and asthenozoospermia if serum concentration should fall below 50 nmol/L (normal range up to 125 nmol/L). High concentration of vitamin D and its metabolites in decidua during the 1st trimester suggests its important role in the implantation process and a local immunological embryo-protection. On the other hand, evidence-based research did not prove a significant difference so far in ovulation stimulation or embryo development depending on vitamin D level. In one of the publications, it was also found that vitamin D binding protein (VDBP) has a molecular similarity to anti-sperm antibodies, and another one concluded that both low (<50 nmol/L) and high (>125 nmol/L) concentration of vitamin D are associated with decreased number and quality of spermatozoa in semen. Vitamin D is definitely not a Trojan Horse in reproductive health, since there were no adverse effects reported for vitamin D intake of up to 10,000 IU/day, but to proclaim it the Golden Fleece, more evidence is needed.
Highlights
The role of vitamin D in fertility treatment has been recently described in some comprehensive reports [1,2]
Current research on the role of vitamin D in fertility impairments, such as polycystic ovary syndrome, uterine fibroids, improper semen parameters and in the case of in vitro treatments and pregnancy failure, suggests it plays an important role in human reproduction processes
Vitamin D supplementation is advised in infertility therapy in both partners
Summary
The role of vitamin D in fertility treatment has been recently described in some comprehensive reports [1,2]. Numerous publications proclaim this particle a panacea for various mental and somatic chronic diseases, while other advise caution in prescribing it to some groups of patients. Should its supplementation become a golden standard in fertility treatment, or do we still need more evidence on its effect?. PCOS remain unknown, but cholecalciferol supplementation improves their insulin resistance and the effects of infertility treatment. Since classical development of medicine in 1920, Vitamin D (cholecalciferol, VD). At the verge of the 21st century, rickets was sporadically observed in Europe.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
