Abstract
B and T lymphocyte activation mediated through the antigen receptor orchestrates integration of the cell cycle, transcription and differentiation. Furthermore antigen receptor elicited changes in the actin cytoskeleton contribute to the formation of lipid rafts, the movement and directional release of secretory granule contents and the movement of lymphocytes themselves1,2Small GTPases of the Ras HOmolog (Rho) family are widely recognised as regulators of the cytoskeleton, transcription and cell cycle. Rho proteins, including RhoA, Rac-1, Rac-2 and Cdc42 have been shown to regulate the survival, proliferation and differentiation of lymphocytes3. Biochemically, Rho GTPases function as molecular switches, shuttling between an “inactive” GDP-bound state and an “active” GTP-bound state and GTP-bound Rho proteins bind to and control the activity of a great number of effector proteins4,5
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