Abstract
Vascular endothelial growth factor (VEGF) genes regulate proliferation of vascular endothelial cells, hence, are essential for both physiological and pathological angiogenesis. The aim of the present study was to examine the association between three common VEGF single nucleotide polymorphisms (-583 T/C, -1154 G/A, and 936 C/T) and the risk of RSA in Saudi women. A total of 200 women; 100 with RSA-patient matched with 100 controls were enrolled sequentially. Genotyping was conducted using TaqMan assay in order to detect single nucleotide polymorphism (SNPs) in DNA extracts from blood samples. Results showed that the +936C/T allele of VEGF gene is not associated with increased risk of RSA. On the other hand, polymorphisms within -583T/C and -1154G/A of the promotor region were significantly associated with increased RSA risk. Based on these it can be concluded that polymorphisms of VEGF are associated with increased risk of RSA in Saudi women. Hence VEGF gene polymorphism can be a useful biomarker to predict susceptibility to RSA.
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