Abstract
BackgroundNeonatal hyperbilirubinemia (NNH) is a common disease in newborns. This research study aimed to assess the associations between uridine diphospho-glucuronate-glucuronosyltransferase 1A1 (UGT1A1, c.-3279 T > G) polymorphisms and NNH risk.MethodsWe searched PubMed, the Cochrane Library, and the Embase electronic databases. All published eligible studies before July 1, 2019, were searched for this meta-analysis.ResultsWe identified 7 independent studies including 1560 cases. The data showed that in the general population, compared with the GT + GG vs TT and GG vs TT, c.-3279 T > G (rs4124874) was significantly related to a higher NNH risk (GG vs TT: OR = 1.865, 95% CI: 1.031–3.373, P = 0.039; GT + GG vs TT: OR = 1.331, 95% CI: 1.055–1.679, P = 0.016). Although not statistically significant, the data showed that c.3279 T > G had a tendency to be associated with NNH under the allele model and GG vs GT + TT in the overall population (G vs T: OR = 1.288, 95% CI: 0.982–1.689, P = 0.067; GG vs TT + GT: OR = 1.583, 95% CI: 0.947–2.647, P = 0.080).ConclusionThe UGT1A1 gene c.-3279 T > G (rs4124874) polymorphism increased susceptibility to NNH, especially for the comparison of GT + GG vs TT and GG vs TT. In the future, we can use homozygous state of the UGT1A1 gene c.-3279 T > G (rs4124874) polymorphism for the diagnosis and screening of molecular biomarkers in NNH patients.
Highlights
Neonatal hyperbilirubinemia (NNH) is a common disease in newborns
Inclusion criteria and exclusion criteria Articles had to meet the following criteria to be included in the meta-analysis: (1) The relationship between the genetic polymorphism of uridine diphospho-glucuronate-glucuronosyltransferase 1A1 (UGT1A1) (c.-3279 T > G) and the risk of NNH was evaluated; (2) a case-control study; and (3) the control group complies with Hardy-Weinberg equilibrium
The data showed that c.-3279 T > G had a tendency to be associated with NNH under the allele model and GG vs GT + TT in the overall population (G vs T: Odds ratio (OR) = 1.288, 95% Confidence interval (CI): 0.982–1.689, P = 0.067; GG vs TT + GT: OR = 1.583, 95% CI: 0.947–2.647, P = 0.080)
Summary
Neonatal hyperbilirubinemia (NNH) is a common disease in newborns. This research study aimed to assess the associations between uridine diphospho-glucuronate-glucuronosyltransferase 1A1 (UGT1A1, c.-3279 T > G) polymorphisms and NNH risk. Neonatal hyperbilirubinemia (NNH) is complex and involves multiple environmental and genetic risk factors [1,2,3,4]. The uridine diphospho-glucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene encodes bilirubin UDP glucuronosyltransferase, which is the enzyme responsible for bilirubin glucuronidation [9]. Researchers have paid widespread attention to genetic factors that are affected by UGT1A1 variants [4, 8, 10]. 60% of transcriptional activity is reduced at UGT1A1 * 60, so the increased risk of hyperbilirubinemia is inextricably linked to its presence [12]
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