Abstract
Uterine leiomyomas (fibroids) represent the most common reproductive-age benign tumor in women. Two distinct subtypes, which carry a Mediator complex subunit 12 (MED12) mutation (mut-MED12) or with high mobility group AT-hook 2 (HMGA2) overexpression (ov-HMGA2), comprise 85% of all leiomyomas. A universal feature of all leiomyomas is responsiveness to estrogen and progesterone, which function by activating their cognate nuclear receptors ERα and PR, respectively, to increase their binding to regulatory regions of target genes and control their transcription and function.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
