Abstract
For the last 20 years, silica-based mesoporous materials have provided a sound platform for the development of biomedical technology applied to tissue engineering and drug delivery. Their unique structural and textural characteristics, chiefly, the ordered distribution of homogeneous and tunable pores with high surface areas and large pore volume, and their excellent biocompatibility provide an excellent starting point for bone tissue regeneration on the mesoporous surface, and also to load species of interest inside the pores. Adequate control of the synthesis conditions and functionalization of the mesoporous surface are critical factors in the design of new systems that are suitable for use in specific medical applications. Simultaneously, the use of appropriate characterization techniques in the several stages of design and manufacture of mesoporous particles allows us to ascertain the textural, structural and compositional modifications induced during the synthesis, functionalization and post-in vitro assays processes. In this scenario, the present paper shows, through several examples, the role of transmission electron microscopy and associated spectroscopic techniques in the search for useful information in the early design stages of mesoporous systems, with application in the fields of tissue regeneration and drug delivery systems.
Highlights
Accepted: 13 December 2021Research on mesoporous materials is booming, with considerable effort devoted to a wide variety of exciting applications for the well-being of society
Chemistry in confined spaces, which became especially important in the 1970s due to technology based on zeolites, was the basis for a great deal of experimental work
The aim of this paper is to review how the ensemble of transmission electron microscopy and associated energy dispersive (EDS) and energy loss (EELS) tools have been very useful to elucidate details on the textural, structural, microstructural and compositional properties of mesoporous materials for biomedical applications in the fields of tissue regeneration and drug delivery in collaboration with Professor Vallet-Regí
Summary
Accepted: 13 December 2021Research on mesoporous materials is booming, with considerable effort devoted to a wide variety of exciting applications for the well-being of society. A whole range of materials has emerged from the discovery of these mesoporous solids, from catalytic to medical [1] and nanotechnological [2] applications. In 1972, Mobil Corporation developed a procedure to transform methanol into gasoline using Zeolite Socony Mobil (ZSM-5) as a catalyst [3]. During this period, research was focused onto discover materials with large pores, and the first mesoporous silica material was produced. Research was focused onto discover materials with large pores, and the first mesoporous silica material was produced These porous silica solids were obtained by combining the inorganic silica component with amphiphilic surfactant molecules [4,5]
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