Abstract
Background Cold hypersensitivity is a common symptom of inflammatory pain and neuropathic pain,however,the underlying mechanism of which remains unclear.Objective To explore the roles of transient receptor potential cation channel,subfamily A,member 1(TRPA1) and transient receptor potential melastatin 8(TRPM8) in cold hypersensitivity.Content The previous literatures on the molecular structure and gating mechanism of TRPA1 and TRPM8,the role in cold hypersensitivity in noxious cold,inflammatory pain and neuropathic pain were reviewed.Trend Progress in the study of TRPA1 and TRPM8 in cold hypersensitivity will contribute to clarify the pathogenesis of cold hypersensitivity,and thus to provide theoretical foundation for the discovery of promising antagonists. Key words: Cold hypersensitivity; Transient receptor potential cation channel, subfamily A, member 1; Transient receptor potential melastatin 8; Inflammatory pain; Neuropathic pain
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