Abstract
Brain glioma is the most common type of tumor that grows from glial tissue, which is made up of auxiliary cells of the nervous system. Gliomas account for about 60% of all tumors located in the brain. Toxoplasma gondii is a parasite, the favorite location of which is the mammalian brain. In the tissues where the parasite is located, necrotic areas, cysts are formed, lesions of the brain and spinal cord, eyes and muscles are fixed. The mechanical, chemical influence of toxoplasmas leads to impaired brain activity, blindness, myositis, and myocarditis. By now, it has not been studied whether the parasite can influence the regulation of carcinogenic processes at the molecular and genetic level. The experiment showed that toxoplasmosis can lead to an increase in the expression of the proto-oncogenes survivin (BIRC5), VEGF, ErbB-2/HER2-Neu, GLI in the tissues of tumors, lungs, liver, spleen, and brain during the de-velopment of an experimental carcinogenic process. Infection of rats with glioma by toxoplasma is accompanied by a decrease in the expression of the anti-oncogene TP53 in the tumor tissues with its simultaneous growth in the lungs, liver, spleen, and brain.
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