The role of top-down control in different phases of a sensorimotor timing task: a DCM study of adults and adolescents

Abstract

The ability to precisely coordinate motor control to regularly-paced sensory stimuli requires an ability often called 'mental timekeeping', a distinct form of cognitive function. A consistent feature among conceptual models of the internal clock mechanism is an element of 'top-down' cognitive control. Although lesion and fMRI studies have provided indirect evidence supporting the role of the prefrontal cortex in exerting top-down influence over lower-level sensory and motor regions, little direct evidence exists. We investigated changes in Dynamic Causal Modeling (DCM)-measured top-down control of sensorimotor timing during different phases of a unimanual, auditory-paced finger-tapping task in a cohort of healthy adults and adolescents. The brain regions examined were organized into a network of excitatory connections between bilateral dorso- and ventrolateral prefrontal cortices and motor and auditory cortices. This baseline connectivity changed depending on whether participants listened passively to the pacing cue, synchronized their regular interval finger tapping with the cue, or continued tapping in absence of the cue. Subjects who performed better at maintaining the prescribed tapping pace in the absence of the auditory cue relied more on top-down control of the motor and sensory regions, while those with less accurate performance relied more on sensory driven, bottom-up control of the motor cortex. No significant maturational effects were observed in either the behavioral or DCM path weight data. Both right and left prefrontal cortex were found to exert control over timing behavioral accuracy, but there were distinctly lateralized roles with respect to optimal performance.