Abstract
The role of thromboxane A 2 (TxA 2) in CCl 4-induced liver disease was investigated in mice. Significant elevation of TxB 2 in the liver was observed 6 hours after the injection of CCl 4. Administration of OKY-046, a selective TxA 2 synthetase inhibitor (10 and 50 mg/kg) and ONO-3708, a TxA 2 receptor antagonist, (0.5, 1 and 2 mg/Kg) suppressed the elevation of serum GOT and GPT levels and histopathological changes of the liver. In addition, OKY-046 inhibited the elevation of TxB 2 in the liver. When U-46619, a stable TxA 2 mimetic was injected i.v. into the mice, clear elevation of serum GOT and GPT levels and histopathological score of the liver were observed. These results suggest that TxA 2 play a role for the onset of CCl 4-induced liver injury in mice.
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