The role of thrombophilia in the genesis of reproductive losses

Abstract

Objective. Defining the role and frequency of acquired and genetic thrombophilia in the genesis of fetal loss syndrome. Methods. 49 pregnant women with a syndrome of reproductive losses and 27 pregnant women with normal reproductive function were examined. The identification of genetic forms of thrombophilia was performed by the method of molecular genetic analysis in 3 phases. Results. In 31 pregnant women of the main group (63,3 %) and 9 pregnant women in the control group (33,3 %) were the presence of acquired, genetically determined or multigeneration. Conclusion. Our analysis of clinical material showed a high frequency of complications and outcomes of pregnancy in women with thrombophilia and fetal loss syndrome and a possibility to avoid the above complications and poor pregnancy outcomes.