Abstract
Correlative biochemical experiments were undertaken in order to explain the electrophysiological effect of pyrithiamine, an antimetabolite of thiamine, on the rabbit vagus nerve. It was shown that pyrithiamine had no effect on the activity of pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, or transketolase, the three enzyme systems that require thiamine pyrophosphate as a coenzyme. The action of the antimetabolite however was found to correlate with its ability to displace thiamine from the nerve. This activity is discussed in relation to the possible function of thiamine in nerve conduction.
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