Abstract
Picrotoxin (25, 50 and 100 ng), injected unilaterally into the posterior part of the substantia nigra pars reticulata (SNR) of rats, evoked a dose-dependent catalepsy. The catalepsy evoked by 100 ng of picrotoxin injected into the SNR was abolished by a subsequent bilateral injection of the same drug (200 ng) into the ventromedial thalamic nuclei. It is suggested that impulses pertinent to the catalepsy evoked from the SNR are transmitted via a GABAergic pathway to the ventromedial thalamic nucleus, wherefrom they reach the striatum, as had been shown previously.
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