Abstract
Neonatally thymectomized mice and sham-operated mice were inoculated at various ages with various doses of either commercial vaccine or live Japanese encephalitis virus (JEV). Groups of neonatally thymectomized mice were found to have depressed capacity to produce circulating antibody as measured by hemagglutination inhibition test. Furthermore, it could be noted that the survival rate was high in groups in which the serum conversion rate was high, irrespective of the thymectomy at birth. From the results a humoral type of resistance against JEV infection was suggested as the basis for immunity.
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