Abstract
Renal cell carcinoma (RCC) is one of the most common forms of malignant epithelial tumors of this localization. The development of new approaches to the diagnosis, prognosis and treatment of RCC is an topical issue of molecular medicine. The renin-angiotensin system (RAS) is not only an important component of the central and humoral mechanisms of controlling blood pressure and hydroelectrolytic balance, but also refers to the body systems involved in complex carcinogenesis pathways. Researches on the role of RAS in tumor progression are currently the priority. The data on the role of RAS in the development and progression of malignant tumors in the kidneys are being discussed. In this article, we present an overview of data on the role of RAS in the emergence and development of RCC, an analysis of the molecular mechanisms of development and progression of RCC, the prospects for using indicators of the RAS: angiotensin-converting enzymes (ACE), ACE2 and angiotensin II receptors as markers of diagnosis and monitoring of neoplastic transformation processes in the kidney. The prospects for the use of new, effective anticancer drugs with a targeted effect on definite indicators of the RAS of RCC were analyzed.
Highlights
Renal cell carcinoma (RCC) is one of the most common forms of malignant epithelial tumors of this localization
The development of new approaches to the diagnosis, prognosis and treatment of RCC is an topical issue of molecular medicine
The renin-angiotensin system (RAS) is an important component of the central and humoral mechanisms of controlling blood pressure and hydroelectrolytic balance, and refers to the body systems involved in complex carcinogenesis pathways
Summary
Renal cell carcinoma (RCC) is one of the most common forms of malignant epithelial tumors of this localization. For citation: Kogan M.I., Akhokhov Z.M., Chernogubova E.A. et al The role of the renin-angiotensin system in the appearance and progression of renal cell carcinoma: a literature review. В различных злокачественных опухолях человека экспрессированы основные компоненты РАС, такие как ангиотензинпревращающие ферменты (АПФ) и рецепторы ангиотензина II (Aнг-II) [8, 11,12,13,14]. Обсуждаются также данные о роли РАС в развитии и прогрессии злокачественных новообразований в почках [15,16,17].
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