Abstract
Duodenal souring induced simultaneously withShay's operation totally prevents the development of ulcers. In animals previously fed a tryptophan-ormethionine-deficient diet, respectively, this antiulcerogen effect showed a considerable decrease. In control animals the protective effect of duodenal souring is associated with the effect of activated tissue hormones inhibiting the gastric secretion and improving the blood supply of the stomach whereas the absence of this protective effect in animals fed a deficient diet may be explained by the disturbance in parahormone synthesis due to protein-deficiency. According to our opinion protein-deficient diet predisposes to ulceration on the one side, because it produces a disturbance in the synthesis of intestinal parahormones.
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