Abstract
Current pathology practice is being shaped by the increasing complexity of modern medicine, in particular of precision oncology, and major technological advances. In the “next-generation technologies era”, the pathologist has become the person responsible for the integration and interpretation of morphologic and molecular information and for the delivery of critical answers to diagnostic, prognostic and predictive queries, acquiring a prominent position in the molecular tumor boards.
Highlights
Introduction in the Generation Era of TumorIn 1953, Crick and Watson’s discovery of the DNA double-helix [1] set a milestone in the history of medicine, deeply transforming the way diseases were viewed
As the advent of the microscope led to the engendering of tissue and cellular pathology becoming a thing of the past, the recent introduction of genomic high-throughput technologies in clinical practice is leading the way to a “next-generation” molecularly driven era of pathology
In order to take the lead in the genomic transition, pathologists must be equipped with the ability to interpret molecular data and exploit molecular technologies and willing to expand their horizons to other scientific disciplines, such as bioinformatics and artificial intelligence
Summary
In 1953, Crick and Watson’s discovery of the DNA double-helix [1] set a milestone in the history of medicine, deeply transforming the way diseases were viewed. As the advent of the microscope led to the engendering of tissue and cellular pathology becoming a thing of the past, the recent introduction of genomic high-throughput technologies in clinical practice is leading the way to a “next-generation” molecularly driven era of pathology. This “molecular revolution” is providing pathologists with the unique opportunity to gain a novel pivotal role in the therapeutic decision-making process and to be the main actors of the translation of biomarkers discovery into clinical application.
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