The role of the microbiome in the contribution of progression in cervical neoplasms

Abstract

The microbiome plays a crucial role in controlling viral infections like the Human Papillomavirus. Getting infected by HPV is not always necessary or not sufficient for the progression of cervical cancer. According to many kinds of research, it was shown that the presence of Human papillomavirus infection is not always connected to the abundance of Lactobacilli and L. gasseri. Besides that some research data suggests an association of cervicovaginal microbiome to viral infections, there are very few things clear about the exact role of the microbiome in carcinogeneses and also about mechanisms and consequences, which are responsible for the HVP persistence and elimination. Recently there are invoked some theoretical models about the Virus-Bacteria-host organism interaction and virus-associated neoplasms are classified into five major types. The characteristics, features and variability of how the cervical epithelial cells maintain to discover various types of pathogen configuration receptors are still under research such as pathogen configuration detection receptors toll-like receptor family (TLR), Retinoic acid-inducible gene 1 (RIG-1) and Nod-like receptor family (NOD). There is a lot more to study thoroughly about how all of these receptors are functioning in virus inducible lesions and what kinds of influences do they have on virus persistence and neoplastic progression