Abstract
1 Eight beta-adrenoceptor blocking agents were compared for their ability to antagonize arrhythmias induced by bolus injections of CaCl2 in rats. 2 Only those beta-blockers possessing local anaesthetic properties were effective in antagonizing this type of arrhythmia and there was a highly significant correlation between antiarrhythmic and local anaesthetic properties. 3 Effects on adrenoceptors seem to play only a minor role in the genesis of this type of arrhythmia.
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