Abstract
Angiogenesis is a processes of new capillary formation from preexisting vessels in response to cytokine stimuli. It involves the breakdown of the surrounding basement membrane, proliferation and migration of the endothlial cells which comprise the vessel wall toward the angiogenic stimulus, and subsequent secretion of basement membrane, leading to the formation of a new capillary branch. This process is dynamic, rather than occurring in discrete steps. Angiogenesis is necessary for many physiological (development, reproductive cycle) and pathological (tumor growth and metastasis, wound healing) processes. Previously, several investigators have explored the use of angiogenic agonists in the revascularization of ischemic tissue. We have recently examined in vivo the ability of SIKVAV (a peptide derived from the alpha chain of laminin-1) to revascularize ischemic tissue. In this manuscript, we review the work done with SIKVAV and its role in angiogenesis as it pertains to the revascularization of ischemic tissue.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
