Abstract
Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is related to purine metabolism disorders or uric acid excretion disorders. Current studies have shown that the intestine is an important potential organ for the excretion of uric acid outside the kidneys. The excretion of uric acid of gut is mainly achieved through the action of uric acid transporters and the catabolism of intestinal flora, which plays an important role in the body’s uric acid balance. Here we reviewed the effects of intestinal uric acid transporters and intestinal flora on uric acid excretion, and provide new ideas for the treatment of hyperuricemia and gout.
Highlights
Gouty arthritis is an inflammatory disease caused by the deposition of sodium urate crystals in and around the joints caused by long-term hyperuricemia [1]
Current research suggests that the impact of intestinal flora on gout is mainly achieved through the following three aspects: participation in purine metabolism and decomposition of uric acid to reduce uric acid levels; metabolites produced by intestinal flora promote the excretion of uric acid (Figure 3); participation in immuneinflammatory regulation of gout
The decrease in intestinal uric acid excretion will increase the burden on the kidneys
Summary
Reviewed by: Zhu Chen, University of Science and Technology of China, China Jinhui Tao, University of Science and Technology of China, China. Role of the Intestine in the Development of Hyperuricemia. Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is related to purine metabolism disorders or uric acid excretion disorders. Current studies have shown that the intestine is an important potential organ for the excretion of uric acid outside the kidneys. The excretion of uric acid of gut is mainly achieved through the action of uric acid transporters and the catabolism of intestinal flora, which plays an important role in the body’s uric acid balance. We reviewed the effects of intestinal uric acid transporters and intestinal flora on uric acid excretion, and provide new ideas for the treatment of hyperuricemia and gout
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