Abstract
Background: To investigate the role of glutamate in the transient focal cerebral ischemia, a reversible middle cerebral artery occlusion madel was induced in 25 male Sprague-Dawley rats. Methods : Triphenyltetrazolium chloride (TTC) stain was used for evaluation of the changes of infarctian ratio in MK-801 (0.3, 1.0, 3.0 mg/kg) or pentylenetetrazole (50 mg/kg) treated groups. Result : The infarction ratio at 48 hours after 2 hour ttansient focal brain ischemia was 39.2 ± 13.2% in control group and 23,8 ± 4.2, 27.0 ±8.9, and 12.8 + 4.4% in MK-801 (0.3, 1.0, 3.0 mg/kg) groups. In the pentylenetetrazole (PTZ) group, the infarction ratio was 32.6 ± 6.7%. Conclusions : The non-specific glutamate receptor antagonist, MK-801, showed a trend toward dose-dependent improvement, but the FIZ group showed no improvement. From these results, it suggested that glutamate might be partly involved in the mechanisms of ischemia-induced neuronal damage. (Korean J Anesthesiol 2000; 38: 1062~1067)
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