Abstract
Background The early growth response gene-1(Egr-1) is considered to be a triggering mechanism that maintains long term potentiation and activates neurogenesis. The expression of Egr-1 protein is closely associated with the consolidation, reconsolidation and extinction of long term memory. Objective Providing potential research targets for studying the mechanism and treatment of postoperative cognitive dysfunction. Content We review the structure, expression pattern of Egr-1 protein and its roles in learning and memory. Trend Egr-1 plays different roles in different phases of memory, but the specific signaling pathways and their relationship with postoperative cognitive dysfunction deserve further clarification. Key words: The early growth response gene-1; Signal pathway; Learning and memory
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