Abstract
Introduction: the complement system can be a critical factor in the outcome of SARS-CoV-2 viral infection. Many mental illnesses are characterized by systemic sterile inflammation, in which the complement system is an obligatory participant. Purpose: to present an analysis of scientific data on the role of the complement system in the pathogenesis of viral diseases and the characteristics of the course of COVID-19 in mental patients. Material and methods: the keywords “complement system” “SARS-CoV-2”, “inhibition of the complement system”, “COVID-19” “mental illness” were used to search scientific articles in the databases MEDLINE, PubMed and other bibliographic sources. Conclusion: patients with mental illness are at risk due to physiological and mental characteristics, and infection with SARS-CoV-2 can provoke a relapse of the underlying disease. Therapeutic inhibition of complement system will help reduce this risk and reduce the likelihood of severe complications from systemic inflammation caused by this infection.
Highlights
Связь Система комплемента (СК) не ограничивается гемостазом, существу- тическую нервную систему, повышает АД, а также отют и другие взаимодействия, например МАС усиливает ветственен за вазоконстрикцию, фиброз, воспаление, секрецию клетками эндотелия фактора Виллебранда, оксидативный стресс и повреждение тканей
Rev Med Pharmacol Sci. 2020;24(7):4040–4047. doi: trol Study of the ALSPAC Longitudinal Birth Cohort
Summary
Введение: система комплемента может быть критическим фактором, определяющим исход коронавирусной инфекции COVID-19. Цель: представить анализ научных данных о роли системы комплемента в патогенезе вирусных заболеваний и особенностей течения COVID-19 у психически больных. Ключевые слова: система комплемента, SARS-CoV-2, ингибирование системы комплемента, COVID-19, психические заболевания. Роль системы комплемента в патогенезе вирусной инфекции SARS-CoV-2 при психических заболеваниях. Summary Introduction: the complement system can be a critical factor in the outcome of SARS-CoV-2 viral infection. Conclusion: patients with mental illness are at risk due to physiological and mental characteristics, and infection with SARS-CoV-2 can provoke a relapse of the underlying disease.
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