Abstract
The influence of the blood glucose level (BGL) on the voluntary consumption of ethanol by two strains of mice has been investigated. LACG mice show an aversion towards ethanol whereas C57BL mice which are mildly hyperglycaemic show a preference for ethanol. Chronic compulsory ethanol drinking produced hypoglycaemia only in C57BL mice. The oral antidiabetic drugs phenformin and glibenclamide lowered the BGL of C57BL mice which then showed an aversion to ethanol. Raising the BGL of LACG mice by acute alloxan or streptozotocin treatment did not reduce ethanol aversion significantly, but alloxan significantly increased total fluid intake. Diazoxide chronically increased the BGL and slightly increased ethanol consumption in LACG mice. It is concluded that the BGL in C57BL mice may be a factor in determining their innate preference for alcohol. The relationship between alcoholism and diabetes is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
