Abstract
The effect of morphine on the capsaicin-induced cough reflex was studied in μ 1-opioid receptor-deficient CXBK mice. There was no significant difference between the morphine-induced antitussive effect in CXBK mice and C57BL/6 mice, a progenitor strain. Furthermore, the antitussive effects of morphine in both the CXBK and C57BL/6 mice were antagonized by pretreatment with either naloxone of β-funaltrexamine, a μ-opioid receptor antagonist, whereas pretreatment with naltrexonazine, a selective μ 1-opioid receptor antagonist, had no effect. Moreover, naltrindole, a selective δ-receptor antagonist, also had no significant effect on the antitussive effects of morphine in either CXBK or C57BL/6 mice. These results support our previous hypothesis that μ 2-rather than μ 1-opioid receptors are involved in morphine-induced antitussive effects.
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