Abstract
14-3-3 protein is a dimer protein extracted from bovine brain cells, a highly conserved protein prevalent in eukaryotes. There are seven subtypes in mammals, respectively , , , , , and . The subtypes differ in content and function. It was found that the protein interacts with corresponding ligand protein in regulating life activities, such as: cell cycle regulation, cell development, the transmission of cell signal molecules plays an important role. At the same time, related regulators have been developed based on cell-cell interaction. In recent years, the exploration of 14-3-3 protein has been deepening gradually. Inhibition or stabilizers of the 14-3-3 protein in question have been studied or discovered, and have become a new target for treating diseases. This paper reviews the effects of 14-3-3 protein on neurological disease, cardiovascular and cerebrovascular diseases and cancer are reviewed. It is found that protein subtypes affect the occurrence of diseases.
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