Abstract
Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients' quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.
Highlights
Allergic conjunctivitis (AC) is an inflammatory disorder of conjunctivae which negatively affects the family and daily activities and is responsible for significant work and school absenteeism [1, 2]. e prevalence can vary in intensity, seasonality, gender, country, and region [3,4,5,6]
Several reports have shown that AC is closely related to asthma, rhinitis, and other allergic diseases, which seriously affects the quality of life of patients and productivity [5,6,7, 15,16,17]
The incidence of AC is related to many factors. e prevalence of allergic rhinitis, allergic conjunctivitis, and asthma has significantly increased among the general population, especially in developed cities with severe air pollution. is phenomenon supports the link between industrialization and allergic diseases [18]
Summary
Allergic conjunctivitis (AC) is an inflammatory disorder of conjunctivae which negatively affects the family and daily activities and is responsible for significant work and school absenteeism [1, 2]. e prevalence can vary in intensity, seasonality, gender, country, and region [3,4,5,6]. The consensus is that a number of researchers have reported that the incidence of allergic diseases, including various types of allergic conjunctivitis, has increased significantly [7,8,9,10]. Several reports have shown that AC is closely related to asthma, rhinitis, and other allergic diseases, which seriously affects the quality of life of patients and productivity [5,6,7, 15,16,17]. The SAC percentage is 90 percent, and the PAC percentage is 5 percent; in tropical climates, PAC seems to be more common [8, 16] They have a significant impact on the quality of patient’s life and affect social economy [30]. The role of 17 and IL-17 in AC is unclear. erefore, this article will focus on the activation and action of 17 cells in the 2-type immune responses to introduce the immunological mechanism of AC and the new progress in diagnosis and treatment
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