Abstract
Pre-eclampsia (PE) accounts for 14.8% of maternal deaths in South Africa. Tenascin C (TN-C) is an anti-inflammatory cytokine expressed in the extracellular matrix and may be dysregulated in the hyperinflammatory PE microenvironment. This study examined serum TN-C in normotensive pregnant (n=36) and pre-eclamptic (n=36) HIV positive and negative women using an immunoassay. TN-C was significantly upregulated in PE vs normotensive pregnant women (p=0.0075) and HIV-positive vs negative pregnant women (p=0.0009). TN-C levels across all groups was statistically different (p<0.0001). This study demonstrates an elevation of TN-C in HIV-associated PE. The potential benefit of TN-C as a biomarker to detect PE development requires investigation.
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