Abstract
TBX3 is a transcription factor in the T‐box gene family. Mutations of TBX3 in humans are associated with Ulnar‐Mammary syndrome, an autosomal dominant condition with multiple organ abnormalities. The recent studies showed that overexpression of TBX3 is associated with breast cancer, probably by interacting with HDACs and inhibiting p14ARF. The tumor suppressor p14ARF is a vital biomarker for cancer development. To determine if the misregulation of TBX3 gene expression could disrupt the expression of tumor suppressor p14ARF in human liver carcinoma cells, we established an inducible expression of the TBX3 cell model with the Tet‐off Advanced System. The results showed that the expression of endogenous p14ARF in human liver carcinoma cells was suppressed by TBX3 in a dose‐dependent manner. This experiment will facilitate our understanding of the molecular mechanisms underlying the TBX3‐initiated liver tumorigenesis, as we as provide potential for liver cancer diagnostics and therapeutics.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
