Abstract
Tau is linked to many chronic neurodegenerative disorders of the CNS with some recent evidence that this may also be the case for Huntington's disease (HD) We have undertaken a number of post mortem studies to look for tau pathology in HD brain and how this varies with region and disease stage. In addition, we have undertaken studies using the EURO-HD database to explore the relationship between tau haplotype and clinical course. Tau pathology is seen in the HD brain, even at relatively early stages and in young patients. In addition, tau haplotype is associated with cognitive changes over time. Tau pathology is seen in HD and seems to be a common feature of the condition with evidence that it may be important in the expression of some of its clinical features, especially cognition.
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