Abstract
Introduction: Survivin (SVV) is a unique member of the inhibitor of apoptosis (IAP) family of proteins which functions as both an inhibitor of apoptosis and a regulator of mitosis, and is upregulated in many cancers. Recent work from our lab suggests that SVV plays a critical role in the vascular injury response via mechanisms that depend, at least in part, on platelet-derived growth factor (PDGF) signaling. We speculate that SVV is a central point of convergence of multiple signaling pathways in vascular injury, and that it also regulates the local amplification of these pathways in the vessel wall.
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