Abstract
Many properties of biological membranes have been explained in terms of the concepts of surface chemistry. The particular case of drug-receptor interactions, i.e., the interaction of specific chemicals with membranes that leads to changes in membrane permeability, has been treated successfully in terms of the mass action approach of the Langmuir adsorption equation. Because of various exceptions to the general equation, several changes have been proposed in the formulation. However, if one considers that the effective drug concentration at a membrane is the surface concentration, some of the exceptions can be shown to be compatible with the Langmuir equation. The use of surface concentrations also suggests an explanation of “cooperativity” in membrane systems, and of the mechanism by which “conformational changes” in membrane proteins control reaction rates.
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