The role of striatal prediction errors in modulating cortical coupling

Abstract

Event Abstract Back to Event The role of striatal prediction errors in modulating cortical coupling Hanneke Den Ouden1*, Jean Daunizeau1, Jonathan Roiser1, Karl Friston1 and Klaus E. Stephan1 1 Radboud University Nijmegen, Donders Centre for Cognitive Neuroimaging, Netherlands Although many studies have reported striatal prediction error responses during different types of learning, their functional significance remains controversial. We combined fMRI and recent advances in computational modeling to investigate how (failures of) learned predictions about visual stimuli influence subsequent motor responses. Healthy volunteers (N=20) discriminated visual stimuli that were differentially predicted by auditory cues. Critically, the predictive strengths of these cues changed over time, requiring subjects to continuously update estimates of stimulus probabilities. This on-line inference, modeled using a hierarchical Bayesian learner, was reflected behaviourally: speed and accuracy increased with predictability of visual stimuli (Fig1A). Furthermore, stimulus selective areas as well as premotor cortex and striatum showed prediction error-related BOLD responses. Using dynamic causal modelling, we demonstrated that striatal prediction errors are used to tune functional coupling during learning. Specifically, the degree of striatal trial-by-trial prediction error activity controls the efficacy of visuomotor connections and thus the influence of surprising stimuli on premotor activity (Fig1B). These findings tie together a physiological mechanism proposed by theories of learning and decision-making, i.e. prediction error-dependent changes in connectivity, and a large body of literature which has described prediction error responses in the striatum. For the first time, we provide evidence for a mechanistic role of the striatum in mediating cortical coupling and gating the transfer of sensory information depending on how well it matches prior expectations. As such, this study lends empirical support to formal theories of brain function postulating that learninginduced reconfiguration of neuronal circuits depends on prediction error dependent synaptic plasticity.Data discussed in this abstract have been accepted for publication in the Journal of Neuroscience, in press. Figure 1: den Ouden HEM, Daunizeau J, Roiser JP, Friston KJ, Stephan KE (2010) Striatal prediction error modulates cortical coupling. Journal of Neuroscience. The role of striatal prediction errors in modulating cortical coupling pic1 The role of striatal prediction errors in modulating cortical coupling pic2 Conference: Computations, Decisions and Movement, Giessen, Germany, 19 May - 22 May, 2010. Presentation Type: Poster Presentation Topic: Posters Citation: Den Ouden H, Daunizeau J, Roiser J, Friston K and Stephan KE (2010). The role of striatal prediction errors in modulating cortical coupling. Front. Comput. Neurosci. Conference Abstract: Computations, Decisions and Movement. doi: 10.3389/conf.fnins.2010.01.00003 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jan 2010; Published Online: 29 Jan 2010. * Correspondence: Hanneke Den Ouden, Radboud University Nijmegen, Donders Centre for Cognitive Neuroimaging, Nijmegen, Netherlands, h.denouden@donders.ru.nl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hanneke Den Ouden Jean Daunizeau Jonathan Roiser Karl Friston Klaus E Stephan Google Hanneke Den Ouden Jean Daunizeau Jonathan Roiser Karl Friston Klaus E Stephan Google Scholar Hanneke Den Ouden Jean Daunizeau Jonathan Roiser Karl Friston Klaus E Stephan PubMed Hanneke Den Ouden Jean Daunizeau Jonathan Roiser Karl Friston Klaus E Stephan Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.