Abstract
The contribution of insect fat body to multiple processes, such as development, metamorphosis, activity, and reproduction results in trade-offs between life history traits. In the present study, age-induced modulation of storage lipid composition in Drosophila melanogaster longevity-selected (L) and non-selected control (C) lines was studied and the correlation between total body fat mass and lifespan assessed. The trade-offs between fecundity, locomotor activity, and lifespan were re-evaluated from a lipid-related metabolic perspective. Fewer storage lipids in the L lines compared to the C lines supports the impact of body fat mass on extended lifespan. The higher rate of fecundity and locomotor activity in the L lines may increase the lipid metabolism and enhance the lipolysis of storage lipids, reducing fat reserves. The correlation between neutral lipid fatty acids and fecundity, as well as locomotor activity, varied across age groups and between the L and C lines. The fatty acids that correlated with egg production were different from the fatty acids that correlated with locomotor activity. The present study suggests that fecundity and locomotor activity may positively affect the lifespan of D. melanogaster through the inhibition of fat accumulation.
Highlights
Aging strongly provokes fat accumulation via reduced insulin sensitivity [1] and inhibition of lipolysis [2], affecting lifespan
The present study suggests that fecundity and locomotor activity may positively affect the lifespan of D. melanogaster through the inhibition of fat accumulation
This study evaluates the age-associated variation in fat storage composition and its impact on lifespan
Summary
Aging strongly provokes fat accumulation via reduced insulin sensitivity [1] and inhibition of lipolysis [2], affecting lifespan. Energy Allocation and Lifespan adult Drosophila has been shown to alter lipid metabolism and increase the lifespan of both males and females [4]. The link between storage lipids and lifespan arises from the contribution of fat-mass-derived signaling factors to the maintenance of insulin sensitivity, lipid metabolism, and energy homeostasis [5]. Reduced fat mass eliminates the risk of agingassociated phenotypes, such as cardiovascular disease, type 2 diabetes, and some types of cancer [5,6,7]. Among fat-mass-derived signaling factors, adipokinetic hormone has a considerable influence in slowing or preventing age-related diseases through stimulating lipid metabolism or reducing the synthesis of lipids [8,9]
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