Abstract
Colorectal carcinoma is one of the most common cancers in the world both in terms of prevalence and mortality. Prospective epidemiological studies have clearly demonstrated that a diet rich in saturated fats and its related lipid metabolism disorders increase the risk of this disease. Chemoprevention is the use of drugs and natural compounds to prevent benign and malignant cancers. Chemopreventive effects with respect to carcinogenesis may be based on: inhibiting inflammatory processes, lowering serum levels of free radicals, suppressing cell divisions, and promoting cell differentiation. Because the prevalence of colorectal carcinoma is growing, a chance for potential chemoprevention raises oncologists’ interest and is a subject of various epidemiological and clinical studies. This paper presents the current state of knowledge regarding potential chemoprevention of this cancer using statin therapy, which is broadly implemented in the present-day pharmacotherapy for cardiovascular diseases. Various pleiotropic effects of statins may in consequence have a positive influence on currently observed negative epidemiological indices of colorectal carcinoma.
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