Abstract
Pre‑mRNA splicing requires the activities of small nuclear ribonucleoproteins and other essential splicing factors. Among these are members of the SR protein family and SR‑related proteins, which are integrally involved in regulating exon recognition, spliceosomal assembly, and spliceosomal re‑ arrangements to promote intron excision. This chapter will focus on the discovery of SR proteins and SR‑related proteins, their structural organization, and their activities in mediating pre‑mRNA splicing. The importance of SR‑proteins in spliceosomal recruitment will be contrasted to other mechanisms resulting in alternative splicing. An additional aspect of the chapter will be a discussion on how reversible phosphorylation of the RS domain dictates SR protein activity and localization.
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