Abstract
Cell-based therapy combined with tissue stem cells and tissue-engineering technology is believed to be a very powerful tool for regeneration of the tooth root and periodontal tissue in the future. The molecular mechanism of tooth root development is useful for this therapy; however, not enough basic information has been accumulated about tooth root development. Reciprocal epithelial-mesenchymal interactions, polarized growth and complicated morphogenic events are involved in tooth development. Recently, a Sonic hedgehog (Shh)-fibroblast growth factor (Fgfs)-dependent regulatory mechanism was found in the developing tooth roots, in a previous report that dental tissues had zone polarizing activity (ZPA) in the chick limb bud. Shh-Fgfs morphogenetic signaling is conserved in the developing molar tooth roots, but a unique combination of Fgfs is used for molar tooth root development compared to the limb bud patterning process.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
