The role of somatostatin receptor type 4 in the adaptation to fasting

Abstract

Event Abstract Back to Event The role of somatostatin receptor type 4 in the adaptation to fasting Zsófia Barcza1, Erika Pétervári1*, Zsuzsanna Helyes2, Miklós Székely1 and Zoltán Szelényi1 1 University of Pécs, Department of Pathophysiology and Gerontology, Medical School, Hungary 2 University of Pécs, Department of Pharmacology and Pharmacotherapy, Medical School, Hungary Somatostatin is a well-known somatotrop hormone inhibitor, but the peptide is ubiquitous in the body with variable effects from inhibition of gastrointestinal (GI) motility and absorption to suppression of neurogenic inflammation and locomotor activity, etc. The five subtypes of somatostatin receptors (SSTR1-5) are expressed in a tissue specific manner and play different roles. SSTR4 has been proven to be devoid of endocrine activity, while being an important regulator of inflammatory processes. Previous studies indicated a suppressor function of SSTR4 on capsaicin-sensitive, transient receptor potential vanilloid 1 (TRPV1) receptors, that were also implicated in the regulation of energy homeostasis according to our data. Now, we aimed to investigate the possible role of SSTR4 in energy homeostasis and adaptation to fasting. The effects of a 48-h fasting was studied on food intake (FI) and body weight (BW) in 4 months old C57BL6 (wild type, WT) and SSTR4 knock-out (KO) mice. In a biotelemetric system core temperature (Tc) and locomotor activity (ACT) were also monitored. Under control conditions, daily FI, BW development, circadian Tc and ACT values did not differ in the two groups. Although the fasting-induced decrease in BW was similar in both groups, Tc of KO mice showed a significantly larger fall. On the other hand, ACT of the KO animals increased significantly compared with WT mice. Upon re-feeding, FI of the KO group was smaller. Our results suggest that SSTR4 activity interferes with adaptation to fasting. Improved adaptation in KO animals was indicated by deeper Tc, enhanced Act (presumably search for food) and diminished re-feeding, however, KO mice lost comparable amounts of BW as WT animals. The better metabolic adaptation may have been counterbalanced by increased activity and GI motility. Further investigations should be carried out concerning the role of SSTR4 in energy homeostasis. OTKA T62598, GVOP-3.2.1.-2004-0271/3.0. Conference: IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010. Presentation Type: Poster Presentation Topic: Homeostatic and neuroendocrine systems Citation: Barcza Z, Pétervári E, Helyes Z, Székely M and Szelényi Z (2010). The role of somatostatin receptor type 4 in the adaptation to fasting. Front. Neurosci. Conference Abstract: IBRO International Workshop 2010. doi: 10.3389/conf.fnins.2010.10.00079 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 Apr 2010; Published Online: 21 Apr 2010. * Correspondence: Erika Pétervári, University of Pécs, Department of Pathophysiology and Gerontology, Medical School, Pécs, Hungary, erika.petervari@aok.pte.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Zsófia Barcza Erika Pétervári Zsuzsanna Helyes Miklós Székely Zoltán Szelényi Google Zsófia Barcza Erika Pétervári Zsuzsanna Helyes Miklós Székely Zoltán Szelényi Google Scholar Zsófia Barcza Erika Pétervári Zsuzsanna Helyes Miklós Székely Zoltán Szelényi PubMed Zsófia Barcza Erika Pétervári Zsuzsanna Helyes Miklós Székely Zoltán Szelényi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.