The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models.

Lucía Sánchez-Salvador,Santiago Mora,Manuela Olmedo-Córdoba,Ángeles Prados-Pardo,Elena Martín-González,Margarita Moreno

doi:10.3390/ijerph18094953

Lucía Sánchez-Salvador, Santiago Mora + Show 4 more

Open Access

https://doi.org/10.3390/ijerph18094953

Copy DOI

Abstract

Inhibitory control deficit and impulsivity and compulsivity behaviours are present in different psychopathological disorders such as addiction, obsessive-compulsive disorders and schizophrenia, among others. Social relationships in humans and animals are governed by social organization rules, which modulate inhibitory control and coping strategies against stress. Social stress is associated with compulsive alcohol and drug use, pointing towards a determining factor in an increased vulnerability to inhibitory control deficit. The goal of the present review is to assess the implication of social stress and dominance on the vulnerability to develop impulsive and/or compulsive spectrum disorders, with the aid of the information provided by animal models. A systematic search strategy was carried out on the PubMed and Web of Science databases, and the most relevant information was structured in the text and tables. A total of 34 studies were recruited in the qualitative synthesis. The results show the role of social stress and dominance in increased drug and alcohol use, aggressive and impulsive behaviour. Moreover, the revised studies support the role of Dopaminergic (DA) activity and the alterations in the dopaminergic D1/D2 receptors as key factors in the development of inhibitory control deficit by social stress.

Highlights

Inhibitory control deficit is associated with impulsive and compulsive behaviours.Impulsive behaviour is defined as the tendency to act prematurely without foresight, often associated with addiction to substance use, attention-deficit/hyperactivity disorder (ADHD), mania and antisocial behaviour [1,2]
According to the literature found, we collated and organized the results on social stress and dominance in preclinical models focusing on aggressive impulsivity and inhibitory control deficit associated with impulsive and compulsive drug intake
Assessed Roman high avoidance (RHA) and Roman low avoidance (RLA) rats with different coping styles and impulsivity phenotypes to study the effects of social defeat stress

Summary

Introduction

Inhibitory control deficit is associated with impulsive and compulsive behaviours.Impulsive behaviour is defined as the tendency to act prematurely without foresight, often associated with addiction to substance use, attention-deficit/hyperactivity disorder (ADHD), mania and antisocial behaviour [1,2]. Inhibitory control deficit is associated with impulsive and compulsive behaviours. Compulsivity is defined as actions inappropriate to the situation that persist and have no obvious relationship to the overall goal, which often result in undesirable consequences [1,3,4]. It is present in obsessive-compulsive disorder (OCD) and in addiction by compulsive drug-seeking and relapse [3,5]. Numerous studies have linked inhibitory control problems with socialization disorders [6,7,8]. Few studies have assessed the role of social stress on the different facets of inhibitory control deficit

Objectives

Methods

Results

Discussion

Conclusion