Abstract
Purpose: Osteoarthritis (OA) presents as a change in the chondrocyte phenotype and an imbalance between anabolic and catabolic processes. Factors such age affect onset and progression. Classically small nucleolar RNAs (snoRNAs) direct chemical modification of RNA substrates and enable endoribonucleolytic pre-rRNA processing. However, characterization of diverse non-canonical snoRNA functions are increasingly becoming elucidated; regulation of chromatin structure, mediators of oxidative stress and microRNA-like functions.
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