Abstract
to conduct morphohistochemical and immunohistochemical study of arterial unstable atherosclerotic plaques for assessment of the state of smooth muscle cells (SMC) and macrophages. The surgical material of the peripheral arteries (femoral, popliteal, external carotid) was obtained from 50 patients aged over 60 years, followed by morphohistochemical, immunohistochemical studies. Hyperplasia of secretory smooth muscle cells (SMC), and new formation of thin-walled capillary vessels was noted in unstable atherosclerotic plaques. Macrophagic infiltration was detected in the intima of arteries, in places of accumulation of foam cells. Unstable atherosclerotic plaque is a cellular-intercellular process with the participation of lipids, macrophages, and with predominance of SMC and newly formed vessels.
Highlights
from 50 patients aged over 60 years
new formation of thin-walled capillary vessels was noted in unstable atherosclerotic plaques
Macrophagic infiltration was detected in the intima of arteries
Summary
Целью нашего исследования было морфологическое, гистохимическое, иммуногистохимическое изучение нестабильных АСБ для оценки состояния ГМК и макрофагов. Результаты Данная группа больных была отобрана в связи с наличием после морфологического исследования признаков нестабильной атеросклеротической бляшки для оценки состояния макрофагов, гладкомышечных клеток, липидов, сосудов в ее структуре. В средней оболочке артерий отмечалась диффузная инфильтрация кислыми гликозаминогликанами с признаками выраженной гиперплазии ГМК, окруженных тонкостенными новообразованными сосудами капиллярного типа
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