Abstract
doi: 10.17691/stm2015.7.4.14 Received April 7, 2015E.V. Makarova, md, Phd, Associate Professor, department of internal diseases PropedeuticsNizhny Novgorod State medical Academy, 10/1 minin and Pozharsky Square, Nizhny Novgorod, 603005, Russian FederationThe aim of the investigation was to study the alterations in the serum level of soluble intercellular adhesion molecules (siCAm) under the influence of smoking and to assess the role of the revealed impairment in the formation and development of chronic obstructive pulmonary disease (CoPd).Materials and Methods. The study included 82 smokers (24 women and 58 men aged 19 to 72 years) and 52 healthy non-smoking donors (17 women and 35 men aged 20 to 57 years). The smokers were divided into the following groups: 1) smokers with normal lung function (mean smoking index of 11.2±4.3 pack-years) — 32 patients; 2) smokers with airflow limitation (CoPd patients) with smoking index of <30 pack-years — 17 patients; 3) smokers having airflow limitation (CoPd patients) with smoking index of 30 pack-years — 33 patients. The subjects underwent clinical examination, CAT test, assessment of dyspnea (mmRC) and smoking index (pack-years), pulmonary function test (PFT), chest radiography, microscopic and microbiological examination of sputum. The serum level of soluble intercellular adhesion antigens siCAm-3 (sCd50) total and siCAm-1 (sCd54) total and oligomer were determined by enzyme immunoassay.Results. The smokers of group 1 were found to have elevated levels of sCd54 antigens (oligomer and total) and sCd50 compared to non-smoking donors, which may reflect a stimulatory effect of tobacco smoke on cell migration into the inflammation focus. Total sCd54 antigen was higher in smoking CoPd patients of group 2 than that of the donor group. There was a decrease in all tested molecules in heavy smokers, CoPd patients (group 3), compared to both the control and group 2. There was found a negative correlation between the serum level of sCd50 and smoking index, as well as positive a correlation between the level of total sCd54 and PFT parameters. Smoking intensity affected CoPd progression. in group 3 the patients had higher mmRC dyspnea index and СAT test score; they had more exacerbations during a year, more frequent application of systemic corticosteroids and antibiotics than the patients in other groups.Conclusion. The revealed smoking-induced alterations in the network of soluble intercellular adhesion molecules contribute to the formation and progression of obstructive disorders and chronic inflammation in CoPd. Low level of soluble adhesion molecules is a marker of severe CoPd with frequent exacerbations.Key words: chronic obstructive pulmonary disease; CoPd; soluble intercellular adhesion molecules; siCAm-1; siCAm-3; smoking.For contacts: makarova Ekaterina Vadimovna, e-mail: e_makarowa@mail.ruThe Role of Smoking-Induced ICAM Alterations in COPD Development
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.