Abstract
Abstract Background Long non-coding RNAs (lncRNAs) are transcripts that are longer than 200 nucleotides, but they are not translated to any functional protein. Similar to other genes, the genes coding for lncRNAs contain single nucleotide polymorphisms (SNPs) that might change their function or expression. Methods We searched PubMed/Medline and Google scholar databases to extract the literature about the role of lncRNAs SNPs in human disorders. Results Recent studies have shown an association between many lncRNA polymorphisms and the risk of human diseases. Therefore, these SNPs might be regarded as predictive markers for a range of disorders including cancer, neuropsychiatric disorders, and skin disorders. Conclusions SNPs within several lncRNAs namely H19, MALAT1, ANRIL, HOTAIR, and SNHGs have been associated with the risk of several human disorders.
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