Abstract
ABSTRACT Background: Gastric cancer is the 3rd most common cause of death in men and the 5th common in women worldwide. Today, surgery is the only curative therapy. Currently available advanced imaging modalities can predict R0 resection in most patients, but it can only be detected with certainty in the perioperative period. Aim: To determine the role of serum CK18, MMP9, TIMP1 levels in predicting R0 resection in patients with gastric cancer. Methods:Fifty consecutive patients scheduled for curative surgery with gastric adenocarcinoma diagnosed between 2013-2015 were included. One ml of blood was taken from the patients to analyze CK18, MMP9 and TIMP1. Results: CK18, MMP9 and TIMP1 levels were positively correlated with pathological N and the stage (p<0,05). CK-18, MMP-9 and TIMP-1 averages in positive clinical lymph nodes and in clinical stage 3, were found to be higher than the averages of those with negative clinical lymph nodes and in clinical stage 2 (p<0,05). Conclusion: Although serum CK-18, MMP-9 and TIMP-1 preoperatively measured in patients scheduled for curative surgery did not help to evaluate gastric tumor resectability, they were usefull in predicting N3-stage.
Highlights
Cytokeratins are keratin-containing proteins of the family of intermediate filaments, found in the intracytoplasmic cytoskeleton of the epithelial tissue
The aim of this study was to determine the role of serum CK18, MMP9 and TIMP1 levels in predicting R0 resection in patients with gastric cancer
One day prior to the operation, 1 ml of blood was taken from them to analyze CK18, MMP9 and TIMP1, which were taken for routine investigations, and placed in separator gel-containing biochemical tubes
Summary
Cytokeratins are keratin-containing proteins of the family of intermediate filaments, found in the intracytoplasmic cytoskeleton of the epithelial tissue. With caspase-mediated cell death, the serum level is elevated. Matrix metalloproteinase 9 (MMP-9) disrupts the extracellular matrix and affects almost all aspects of cell biology. MMP-9 is one of the most complex matrix metalloproteinases. The tissue inhibitor of metalloproteinase-1 (TIMP 1) plays a negative role in the invasion and metastasis of tumor cells by forming a 1:1 complex with MMP-9 and inhibiting its enzymatic activity[1,5,10,16,17,18]. Gastric cancer is the 3rd most common cause of death in men, and the 5th in women worldwide[15]. The aim of this study was to determine the role of serum CK18, MMP9 and TIMP1 levels in predicting R0 resection in patients with gastric cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
