Abstract
Serotonin has long been implicated in emotional processing, but its specific mechanism of action is unclear. In this review we briefly summarise current perspectives on the neurobiological role of serotonin at the behavioural, cognitive and neural levels. We provide a general overview of serotonergic molecular pathways before discussing behavioural research delineating a role of serotonin in aversive inhibition. We then outline recent attempts to computationally formalise this role in aversive inhibition at the cognitive level. Finally, we try to situate these effects within neural circuitry. We argue, in particular, that the computational role of serotonin in aversive inhibition may be underpinned by serotonergic inhibition of prefrontal-amygdala circuits. Working to refine and improve our understanding of the neurobiological basis of serotonergic function is critical in order to improve our ability to diagnose and treat psychiatric disorders such as depression and anxiety in which serotonin may play a central role.
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